wiem ze kortyzol obnizaja a jak z testem
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Napisał(a)
ktos wie jaki jest wplyw hormonow tarczycy na poziom testosteronu i wolnego testosteronu?
wiem ze kortyzol obnizaja a jak z testem
wiem ze kortyzol obnizaja a jak z testem
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Napisał(a)
nigdzie w necie nic na ten temat nie ma , chyba pojde zrobic badanie bo biore syntetyczne hormony ze wzgledu na niedoczynnosc tsh obecnie 0,4 , rok temu tsh wynosilo 4,5 , takze rok temu wykonywalem badanie testosteronu wyszlo 449,7 ng/dl normy(249-836) ciekawi mnie jak bedzie teraz od pol roku biore stala dawke novothyral 75+ euthyrox25 wychodzi 100 mcq t4 i 15 mcq t3
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Napisał(a)
ktos moze to przetlumaczyc? Found this tonight:
Thyroid hormones: their role in testicular steroid...[Arch Androl. 2003 Sep-Oct] - PubMed Result
Some very important and intresting quotes:
"T3 directly increases Leydig cell LH receptor numbers and mRNA levels of steroidogenic enzymes and steroidogenic acute regulatory protein. It stimulates basal and LH-induced secretion of progesterone, testosterone, and estradiol by Leydig cells. Steroidogenic factor-1 acts as a mediator for T3-induced Leydig cell steroidogenesis. Although the role of T3 on sperm, germ, and peritubular cells has not yet been completely studied, it is clear that T3 directly regulates Sertoli and Leydig cell functions."
Testicular dysfunction in men with primary hypothy...[Clin Endocrinol (Oxf). 2000] - PubMed Result
"OBJECTIVE: Primary hy
Thyroid hormones: their role in testicular steroid...[Arch Androl. 2003 Sep-Oct] - PubMed Result
Some very important and intresting quotes:
"T3 directly increases Leydig cell LH receptor numbers and mRNA levels of steroidogenic enzymes and steroidogenic acute regulatory protein. It stimulates basal and LH-induced secretion of progesterone, testosterone, and estradiol by Leydig cells. Steroidogenic factor-1 acts as a mediator for T3-induced Leydig cell steroidogenesis. Although the role of T3 on sperm, germ, and peritubular cells has not yet been completely studied, it is clear that T3 directly regulates Sertoli and Leydig cell functions."
Testicular dysfunction in men with primary hypothy...[Clin Endocrinol (Oxf). 2000] - PubMed Result
"OBJECTIVE: Primary hy
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Napisał(a)
Primary hypothyroidism can cause disturbances in normal gonadal function. The aim of this study was to investigate the relationship in men between hypogonadism and primary hypothyroidism and the extent to which free and total testosterone levels rose after introduction of replacement thyroxine. DESIGN: Paired study of patients in a hypothyroid and thyroxine treated state. PATIENTS: Ten men with primary hypothyroidism. MEASUREMENTS: Free and total testosterone, gonadotrophin and prolactin levels before and after thyroxine replacement therapy. RESULTS: Low free testosterone levels (161 +/- 62 pmol/l) demonstrated at the time the men were hypothyroid rose significantly with the commencement of thyroxine replacement (315 +/- 141 pmol/l; P < 0.001). Gonadotrophin levels were not elevated consistent with hypogonadotrophic hypogonadism. Hyperprolactinaemia, which can occur in primary hypothyroidism and cause hypogonadotrophic hypogonadism, was not present in the majority of these patients. However a reduction in prolactin level was evident with thyroxine replacement and a rise in free testosterone levels. CONCLUSION: This suggests an effect of hypothyroidism on gonadotrophin secretion at the level of the hypothalamus-pituitary, either directly or through modulation of prolactin secretion. Low free testosterone may also be a contributing factor to some of the symptoms and signs of hypothyroidism in men."
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